Alzheimer's Disease Receives Clinical Studies

Did you know------The University of California - Irvine scientists are conducting clinical trials to determine Niacin's effect in humans afflicted with Alzheimer's disease. They're reporting Nicotinamide, a form of Niacin also known as vitamin B3, taken in high doses prevented memory loss in mice with Alzheimer's disease. It also lowered levels of a protein (called phosphorylated tau) that leads to the development of brain lesions associated with Alzheimer's disease. The vitamin has the ability to strengthen scaffolding along which information travels in brain cells, helping to keep neurons alive and further preventing symptoms in mice genetically wired to develop Alzheimer's. The study appearing in the Journal of Neuroscience, reports Nicotinamide has a very robust effect on neurons, helping prevent loss of cognition in mice with Alzheimer's disease. Nicotinamide is a water-soluble vitamin and is generally is safe but can be toxic in very high doses. Other clinical trials have shown it benefits people with diabetes complications and has anti-inflammatory properties that may help people with skin conditions. This vitamin belongs to a class of compounds called HDAC inhibitors, which have been shown to protect the central nervous system in Parkinson's and Huntington's diseases and amyotrophic lateral sclerosis. In the nicotinamide study, the scientists tested short-term and long-term memory over time. The vitamin slightly enhanced cognitive abilities, suggesting that not only is it good for Alzheimer's disease, but if normal people take it, some aspects of their memory might improve. Scientists found that the nicotinamide-treated mice in the study had dramatically lower levels of the specific protein that leads to the Alzheimer's" tangle" lesion. The intake of Nicotinamide led to an increase in proteins that strengthen microtubules, the scaffolding within brain cells along which information travels. When this scaffolding breaks down, the brain cells can die. Neuronal death leads to dementia experienced by Alzheimer's patients.
Courtesy: University of California - Irvine (2008, November 4). Vitamin B3 Reduces Alzheimer's Symptoms, Lesions: Clinical Trial On Nicotinamide Effect In Alzheimer's Patients. University of California - Irvine (2008, November 4). Vitamin B3 Reduces Alzheimer's Symptoms, Lesions: Clinical Trial On Nicotinamide Effect In Alzheimer's Patients

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